Amyloid beta-protein: Not just a culprit

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>> Saturday, April 10, 2010

Alpha synuclein ring-like oligomer interacting with the amyloid-beta peptide
The amyloid beta-peptide (Aβ) is the main component of beta-amyloid plague in the brains of Alzheimer’s disease (AD) patients. It is formed by the cleavage of the amyloid precursor protein (APP), a transmembrane glycoprotein with no normal physiological function. β and γ- secretase act susccessively to produce number of Aβ isoforms of which Aβ40 and Aβ42 are the most common.
Aβ accumulates outside and around the neurons giving rise to amyloid plague. These plagues are able to cause the neuronal cell death responsible for various neurodegenerative diseases like alzheimer’s disease (AD). So, it is seen as a culprit behind the AD. But recently, Soscia reported the importance of Aβ as an antimicrobial peptide (AMP).

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