Neuroprotective and antioxidant effects of Pramipexole enantiomers

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>> Saturday, March 20, 2010

Pramipexole is a non-ergot dopamine (DA) agonist that has been used for the treatment of Parkinson’s disease. It exists in two forms; S (-) and R (+) enantiomers. Only S (-) enantiomer acts as D3/D2 receptor agonist. R (+) isomer has not been well studied for the characterization of its pharmacological values.
Recently, Toninelli et. al. has reported that both isomers of pramipexole have similar potency in preventing neuronal cell death induced by H2O2 and act as mitochondria-targeted antioxidants.

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