Delicious fruit with valuable leaves!

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>> Saturday, September 19, 2009

Mangifera indica L. (Anacardiaceae) is one of the most important tropical plants in the world. It is a large tree whose fruits are liked by many people and commonly called as Mango.
Phytochemical research from different parts of M.indica has demonstrated the presence of various polyphenols, phytosterols, flavonoids and this species are widely used for the purpose of analgesic effect, anti-inflammatory, immunostimulant,antioxidant, antidiarrhea etc. Because of its vague biological importance, many researchers are interested in this species.
This post, as per the article (Molecules, 2009, 14, 1098; doi: 10.3390/molecules14031098), reveals the antiulcerogenic action of mentioned species’ leaf decoction on different experimental models in rodents. Previously, they have used the flower part for the study but it results reduced availability of the fruits in the market so they changed it to leaf part.



As an initial study acute toxicity was determined. According to the study it was found that the aqueous decoction of M.indica did not show acute toxicity but exhibited gastroprotective effects against several ulcerogenic agents like NSAIDs, HCl/ethanol solution. After receiving positive biological assay results, the active constituents of the decoction were isolated and characterized as ;
Mangiferin (C-glucopyranoside of 1, 3, 6, 7-tetrahydroxyxanthone (Mi1)


C-glucosylbenzophenone (Mi2)


Mangiferin is a xanthone with various therapeutic activities including antioxidant. It has been proposed that the catechol moiety with a 6, 7 –dihydroxylated structure, together with its aromatic bonds, is responsible for its antioxidant property (Chem.Pharm.Bull., 1992, 721). Similarly, it has been reported that benzophenones have shown the activity against H.pylori (Mol.Cell.biochem, 2003, 243).


Disclaimer: This experiment has been tested only in animal. So it’s inappropriate and unsafe for human use and is highly discouraged at the moment.



1 comment:

  1. Traditionally, we Indians have used mangoes (as antioxidants) unknowingly. Its interesting the 'xanthone' has that property. Thanx for the interesting info.

    ReplyDelete

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