Mechanism of action of Cisplatin (anticancer agents)

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>> Friday, August 21, 2009

Cisplatin, cisplatinum or cis-diamminedichloridoplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including  sarcomas, some carcinomas (e.g.small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin. Platinum complexes are formed in cells, which bind and cause crosslinking of DNA; ultimately triggering apoptosis, or programmed cell death.
Below is the animation on mechanism of action of cisplatin:


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